(2-[2-(Fmoc-Amino)-Ethoxy]-Ethoxy)-Acetic Acid

Name	[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid
Synonyms	Fmoc-AEEA-OH Fmoc-Aeea-Oh Fmoc-Aeeac-Oh Rarechem Em Wb 0032 Fmoc-PEG2-acetic acid 8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID 8-(Fmoc-Amino)-3,6-Dioxa-Octanoic Acid Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Fmoc-8-amino-3,6-dioxaoctanoic acid,Fmoc-AEEA (2-[2-(Fmoc-Amino)-Ethoxy]-Ethoxy)-Acetic Acid 8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID 8-Fluorenylmethoxycarbonylamino-3,6-Dioxaoctanoic Acid 9-Fluorenylmethoxycarbonyl-8-Amino-3,6-Dioxaoctanoic Acid 9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID 8-(9-Fluorenylmethoxycarbonyl-Amino)-3,6-Dioxa-Octanoic Acid 1-(9H-Fuoren-9-Yl)-3-Oxo-2,7,10-Trioxa-4-Azadodecan-12-Oic Acid 1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid 1-(9H-Fluoren-9-Yl)-3-Oxo-2,7,10-Trioxa-4-Azadodecan-12-Oic Acid (2-[2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Ethoxy]-Ethoxy)-Acetic Acid
CAS	166108-71-0
EINECS	200-111-8
InChI	InChI=1/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey	XQPYRJIMPDBGRW-UHFFFAOYSA-N

Molecular Formula	C21H23NO6
Molar Mass	385.41
Density	1.265±0.06 g/cm3(Predicted)
Melting Point	90-92℃
Boling Point	631.4±45.0 °C(Predicted)
Flash Point	335.6°C
Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	8.27E-17mmHg at 25°C
Appearance	White crystal
Color	White
pKa	3.40±0.10(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.579
MDL	MFCD01321015
Physical and Chemical Properties	Storage Conditions:-15 ℃ WGK Germany:3
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29189900

Introduction	[2-[2-(Fmoc-amino) ethoxy] ethoxy] acetic acid is a key intermediate compound for the synthesis of anti-AIDS drug Irabot and diabetes treatment drug Somalutide. This modified PEG and its homologs can also be used in drug research and development, for example, protein drugs, peptide compounds, liposomes, and small molecule drugs can be modified by coupling reactions.
use	[2-[2-(Fmoc-amino) ethoxy] ethoxy] acetic acid is an organic synthesis intermediate and pharmaceutical intermediate, which can be used in laboratory research and development and chemical medicine synthesis process.
biological activity	Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a degradable ADC linker used in antibody drug conjugate (ADC) synthesis. Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.

Last Update：2024-04-09 19:05:10

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